Canagliflozin (CANA) Lowers A1C and Blood Pressure (BP) Through Weight Loss-Independent (WL-I) and Weight Loss-Associated (WL-A) Mechanisms
نویسندگان
چکیده
منابع مشابه
Weight loss and blood pressure control (Pro).
Overweight is an increasingly prevalent condition throughout the world. Current estimates, which are probably conservative, indicate that at least 500 000 000 people worldwide are overweight as defined by a body mass index (BMI) of between 25.0 and 29.9 and an additional 250 000 000 are obese with a BMI of 30.0 or higher.1 In the United States, recent data indicate that as much as 66% of the ad...
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The article in the current issue of Hypertension by Aucott et al1 raises some interesting questions. Does weight loss in the long term (ie, 3 years) result in a decrease in blood pressure (BP) levels? Is there difference in the effect of weight loss on decreased systolic BP (SBP) versus diastolic BP (DBP)? They combined 8 clinical trials and 8 cohort studies and tried to evaluate the linear rel...
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Obesity is a world-wide pandemic and its incidence is on the rise along with associated comorbidities. Currently, there are few effective therapies to combat obesity. The use of lifestyle modification therapy, namely, improvements in diet and exercise, is preferable over bariatric surgery or pharmacotherapy due to surgical risks and issues with drug efficacy and safety. Although they are initia...
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Correlations were made between weight change (as an index of volume loss) and blood pressure (BP) reduction before and after hydrochlorothiazide treatment. A total of 343 patients with mild to moderate hypertension (95-114 mm Hg) received hydrochlorothiazide alone. The diuretic was titrated from 50 to 100 to 200 mg daily as needed until the diastolic BP fell below 90 mm Hg (goal BP) or side eff...
متن کاملInsulin and blood pressure during weight loss in obese adolescents.
The role of insulin in the regulation of blood pressure was evaluated in 50 obese adolescents before and after a 20-week weight loss program. When compared with 10 nonobese adolescents, the obese subjects had significantly higher systolic, diastolic, and mean arterial pressures (p = 0.005), an elevated 24-hour urinary sodium excretion (p = 0.002), an elevated fasting insulin concentration (p = ...
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ژورنال
عنوان ژورنال: Canadian Journal of Diabetes
سال: 2013
ISSN: 1499-2671
DOI: 10.1016/j.jcjd.2013.08.086